In addition to the classical pro-inflammatory cytokines interleukin (IL)-1, IL-6 and Tumor Necrosis Factor (TNF)α, whose role in IMIDs has been amply described (47), the IL-23/17 axis is emerging as a common feature in several IMIDs among which IBD, psoriasis, uveitis, psoriatic arthritis and evidence are accumulating about its role in RA (48, 49). This evidence concerns the gene TNF and psoriasis.