RNPC3 and cancer: Moreover, the presence of specific autoantibodies, such as anti-RNA polymerase III and anti-RNA-binding region-containing protein 3 (RNPC3) in SSc (134, 135), or anti- transcription intermediary factor 1 (TIF1)-γ and anti-nuclear matrix protein 2 (NXP2) in dermatomyositis, could help to stratify patients at higher risk of cancer, as a strong association has been demonstrated (136, 137).