CD8A and type 1 diabetes mellitus: Alternatively, as CD8+ T cells are a major component of islet infiltrate during T1D development in rodents and humans (71–73) and an “exhausted” CD8+ T-cell phenotype is associated with slower disease progression and preservation of β-cells (74, 75), it might be speculated that select iDL signaling additionally facilitates cytotoxic CD8+ T-cell function.