First, when intracellular ferroptosis occurs leading to cellular damage, DAMP (e.g. ATP,HMGB1, etc.)is released and acquires immunogenicity, and is able to bind to pattern recognition receptors, such as Toll-like receptor 4 (TLR4) and purinergic receptor P2X7, to promote activation of inflammation and the innate immune system, and to enhance the anti-tumor through activation of immune system immune effects. The gene discussed is HMGB1; the disease is neoplasm.