First, due to the special environment of the gastrointestinal tract, TFRC is overexpressed in CRC in colorectal cancer, and second, colorectal cancer is the only malignancy that maintains a source of iron uptake, which leads to the presence of excess iron in cells, and ferroptosis is more likely to occur (59).In addition, the ROS content in CRC cells is usually higher than that in other normal cells. Here, TFRC is linked to colorectal carcinoma.