In addition, recent studies have shown that baicalein, triptonide and emodin can target JAK2/STAT3/GPX4,SLC7A11/GPX4 and NCOA4/FTH1 signaling axes to promote ferroptosis in CRC cells, respectively, which provide more possibilities for clinical treatment (94–96). The gene discussed is GPX4; the disease is colorectal carcinoma.