APC serves as a CRC oncogene, and 80% of sporadic CRC have mutations in the APC gene, which has been reported to be involved in IFNγ/IFNGR2/APC/TCF4/GPX4 axis-mediated organoid damage and to inhibit the efficacy of CRC stem cells (CSCs).It has been demonstrated that Eastin and RSL3 can trigger ferroptosis in various CRC cells by inhibiting System Xc- and GPX4 activity, respectively (16). The gene discussed is APC; the disease is colorectal carcinoma.