GPX4 and neoplasm: It is noteworthy that lipid perxides in GPX4-deficient Tregs cells with accumulate lipid peroxides accumulate abnormally and lead to ferrortopsis, impairing Tregs’ intra-tumoral survival, increasing T-cell infiltration into tumors, and enhancing anti-tumor immune responses, suggesting that GPX4 sustains the activation and immunosuppressive function of Tregs in TME to promote tumor immune evasion (46).Furthermore, GPX4-deficient Treg cells increased mitochondrial superoxide production and promoted IL-1β production.