This is expected to provide a prospective therapeutic strategy for the treatment of KARS mutant metastatic colorectal cancer (mCRC) patients (89).The natural product β-Lapachone promotes lipid peroxidation by reducing GSH synthesis through the xCT/GPX4 axis, in addition it promotes ferroptosis in CRC cells through NCOA4-mediated ferritin autophagy (90).The current study by our group also demonstrated that the herbal extract 2’,4’-dihydroxychalcone can affect the proliferation, migration and ferroptosis process of CRC cells through c-myc/CLIC3. The gene discussed is SLC7A11; the disease is colorectal carcinoma.