In addition, the sublethal heat stimulation induced by iRFA may inhibit the IFN‐1 signal in HCC by activating small ubiquitin‐like modifier 2 (SUMO2)‐mediated SUMOylation, potentially inhibiting DC cell maturation and CD8+T cell infiltration (Figure 4F).239. The gene discussed is CD8A; the disease is hepatocellular carcinoma.