Inhibition of cathepsin D was followed by amelioration of mouse dextran sodium sulfate (DSS) colitis (Menzel et al., 2006); the level of anti-cathepsin G antibodies was significantly higher in patients with severe colitis than in those with mild or moderate colitis (p < 0.05) (Kuwana et al., 2000). This evidence concerns the gene CTSG and colitis.