Of note, The IVW analysis provided suggestive evidence for the association between MVK (OR = 0.674, 95% CI = 0.524–0.868, p = 0.002), HMGCS1 (OR = 2.163, 95% CI = 1.182–3.955, p = 0.012), TM7SF2 (OR = 0.895, 95% CI = 0.826–0.970, p = 0.007), and FDPS (OR = 1.477, 95% CI = 1.239–1.761, p < 0.001) and the risk of NAFLD (Table 1). This evidence concerns the gene HMGCS1 and metabolic dysfunction-associated steatotic liver disease.