CASQ2 and atrial fibrillation: In contrast, genetically predicted expression levels of CASQ2 and ALOX15 were associated with reduction in AF risk in atrial appendage tissue (OR 0.652, 95% CI 0.538–0.789; PPH4 = 0.98 and OR 0.915, 95% CI 0.867–0.966; PPH4 = 0.76, respectively).