Genetically predicted higher levels expression of TNFSF10 (OR 1.160, 95% CI 1.074–1.254; PPH4 = 0.65), CDKN1A (OR 1.214, 95% CI 1.125–1.309; PPH4 = 0.64) and ALOX15(OR 1.063, 95% CI 1.028–1.099; PPH4 = 0.60) were positively associated with AF risk. Here, CDKN1A is linked to atrial fibrillation.