Conversely, genetically predicted higher levels expression of TTN (OR 0.291, 95% CI 0.186–0.454; PPH4 = 0.65), PTK2 (OR 0.794, 95% CI 0.730–0.864; PPH4 = 0.67) and ALB(OR 0.291, 95% CI 0.186–0.454; PPH4 = 0.98) were inversely associated with AF risk (Table 2). This evidence concerns the gene TTN and atrial fibrillation.