MAPT and atrial fibrillation: For example, one SD increase in genetically predicted MAPT methylation at cg02228913 was associated with a decreased risk of AF (OR 0.967, 95% confidence interval [CI] 0.955–0.979), whereas one SD increase in genetically predicted MAPT methylation at cg07163735 was associated with a higher risk of AF (OR 1.189, 95% CI 1.101–1.284).