PTEN and obesity due to melanocortin 4 receptor deficiency: MiR-17 is most commonly studied in relation to cancer, which has elucidated evidence for targeting of PTEN in cancer cells (42), and the PTEN protein has well-described associations with obesity and insulin sensitivity (43) and is a predicted target of miR-23a, miR-27a, and miR-320a, which showed longitudinal associations with weight in the study described here.