INS and type 2 diabetes mellitus: Although research indicates that patients with T2DM treated with insulin or insulin secretagogues (such as sulfonylureas and glinides) face a higher risk of hypoglycemia after prolonged high-intensity exercise (32–36), 30 to 40 minutes of moderate-intensity exercise do not significantly raise the risk of hypoglycemia, even in those on long-term insulin therapy (37).