AR and posterior cortical atrophy: Advanced PCa is initially treated with androgen deprivation therapy (ADT) combined with androgen receptor (AR) inhibitors (ARIs), aiming at decreasing androgen concentration and antagonizing AR transactivation to blunt oncogenic effects of AR signaling (Chi et al., 2019; Smith et al., 2022; Hussain et al., 2013; Messing et al., 1999; Eisenberger et al., 1998; Crawford et al., 1989; Davis et al., 2019).