KITLG and cholelithiasis: First, oxidative stress, changes in bile composition, and inflammatory responses downregulate the SCF/c-kit pathway, resulting in the loss of gallbladder ICCs during cholelithiasis, which decreases gallbladder motility (Grover M et al., 2019; Pasternak A et al., 2017; Wan JF et al., 2018).