KITLG and cholelithiasis: Recent findings confirm that oxidative stress and inflammatory responses contribute to the downregulation of the SCF/c-kit pathway, causing injury to the network structure of gallbladder ICCs, reducing their numbers, and ultimately leading to gallbladder dysfunction in cholelithiasis (Liu W et al., 2023; López-Pingarrón L et al., 2023; Xie Y et al., 2021).