Riociguat has been approved as an orally administered soluble guanylate cyclase (sGC) to treat PH and CTEPH by stimulating the NO-sGC-cGMP pathway (Marius M, Michael et al., 2012; Hossein A, Gerd et al., 2015; Nazzareno, Marc et al., 2015; Hossein-Ardeschir, Marc et al., 2016). This evidence concerns the gene SGCB and chronic thromboembolic pulmonary hypertension.