SLC12A3 and Hypertension: The mechanism by which CNIs induce hypertension is linked to the overactivity of the renal sodium chloride cotransporter (NCC) and increased phosphorylation of N-methyl-D-aspartate (NMDA) receptors in the paraventricular nucleus (PVN) of the hypothalamus, leading to heightened sympathetic output (Hoorn et al., 2011; Zhou et al., 2022).