It can also improve the behavioral performance of sleep-disordered rats induced by sleep deprivation in a Y maze, object recognition, and an avoidance test, stimulate the production of anti-inflammatory factor IL-10, reduce the production of pro-inflammatory factors IL-1β, IL-6, and IL-18, and activate microglia and increase the expression of 2-related factor 2 and heme oxygenase-1 (HMOX1). This evidence concerns the gene HMOX1 and sleep disorder.