Symptom categories positively associated with CRP in linear regression were early waking insomnia (HAMD item#4) (B = 0.49, CI 0.15–0.84, P = 0.005), work and activities (HAMD item#7) (B = 0.36, CI 0.11–0.61, P = 0.005), psychomotor retardation (HAMD item#8) (B = 0.30, CI 0.04–0.56, P = 0.026), agitation (HAMD item#9) (B = 0.0.32, CI 0.04–0.59, P = 0.023) and psychic anxiety (HAMD item#10) (B = 0.0.47, CI 0.21–0.73, P ≤ 0.001). This evidence concerns the gene CRP and insomnia measurement.