CRP and major depressive disorder: Inflammation has been shown to induce ‘sickness behaviours’ that mimic symptoms of MDD such as anhedonia, weight and appetite disturbances, fatigue and psychomotor slowing.6 Inflammation has also been associated with cognitive dysfunction, anxiety6 and suicidal ideation.12 Our analysis found early night and early morning insomnia and anxiety remained associated with elevated CRP when controlling for age, BMI, SES and gender.