Width was associated with aggressive clinicopathological parameters as large tumour size (p < 0.004), higher histological grade (p < 0.001), higher stage (P<0.001), poor NPI (p < 0.001), LVI (p < 0.035), NST subtype (p < 0.001), molecular subtype (p < 0.001), hormonal receptors negativity (p < 0.001), HER2 positivity (p < 0.001) and high ki67 (p < 0.001) (Table S5). The gene discussed is NR4A1; the disease is neoplasm.