Straight fibres were correlated with large tumours (p < 0.001), worse NPI (p < 0.001), LVI (p < 0.001), higher grade (p < 0.001), histological subtype (p < 0.004), molecular type (p < 0.001), hormonal receptors negativity, ER (p < 0.005) and PR (p < 0.014), HER2 positivity (p < 0.032) and high ki67 (p < 0.001) (Table S4). This evidence concerns the gene ESR1 and neoplasm.