ESR1 and neoplasm: High fibre density was associated with some aggressive clinicopathological parameters as large tumours (p < 0.004), high grade (p < 0.001), high stage (p < 0.005), poor NPI (p < 0.001), LVI (p < 0.004), histological subtype NST (p < 0.001), molecular subtypes (p < 0.001), ER negativity (p < 0.012), HER2 positivity (p < 0.003) and high ki67 (p < 0.001) (Table S5).