Moreover, CALB2 is not expressed in normal colon cells, but it is expressed in most poorly differentiated colon cancers [51], for example, high levels of expression of CALB2 are observed in medullary carcinoma of the colon with strong focal IHC staining, emphasizing its utility as a biomarker for colon cancer [52]. Here, CALB2 is linked to colon medullary carcinoma.