In line with our previous findings, pathways of inflammatory response, epithelial cell proliferation, positive regulation of calcium ion, and negative regulation of immune, as well as pathways known to be involved in metastasis formation, such as EMT, cell adhesion, and wound healing, were significantly upregulated in Calb2-OE-LM organoids compared to Calb2-OE organoids (Fig. 6F, Supplementary Table S14). This evidence concerns the gene CALB2 and lymphangioma.