Other clinicopathological factors, such as metastasis status or sarcoma subtypes, were infrequently associated with the mutational patterns of TP53, RYR1, IDH1, and SDHA. There was a correlation between Doxorubicin sensitivity and the karyotype of sarcoma cell lines, with complex sarcoma types showing a more Doxorubicin-resistant pattern (Fig. 2A, Table S3A and S3B). The gene discussed is RYR1; the disease is sarcoma.