In addition, we also found a result worth exploring in this study: S100β level was similarly associated with infarct volume in patients with stroke in dominant and non-dominant hemispheres, but it was only independently associated with 24-h higher NIHSS score and 3-month unfavorable outcomes in patients with dominant hemisphere stroke but the association was not significant in those with non-dominant hemisphere stroke. The gene discussed is S100B; the disease is Stroke.