Similarly, Rius et al. investigated the methDNA landscape of invasive melanoma cells and identified a signature of genes with promoter hypermethylation and decreased expression, including Rho-Type GTPase-Activating Protein 22 (ARHGAP22) and Neuron Navigator 2 (NAV2), which were correlated with poor survival in CM patients [44]. Here, NAV2 is linked to cutaneous mastocytosis.