Finally, no significant variation was detected neither for methDNA hotspots nor for the SLC22A17 All Vars/Vars 1, 2, and 3 expression in SK-MEL-28 cells, which were more resistant to 5-Aza treatment compared to the other melanoma cell lines (Fig. 7G, H and Supplementary Fig. S1). This evidence concerns the gene SLC22A17 and melanoma.