SPOP and cancer: Cancer development has been closely linked with phase-separated macromolecular condensates, including stress granules, DNA repair condensates, PRC1 condensates, super-enhancer condensates, SPOP/DAXX bodies and PML puncta (Bergeron-Sandoval et al, 2016; Ong and Torres, 2020; Taniue and Akimitsu, 2022; Zbinden et al, 2020).