In a recent study, Yoshida et al., examined the association of cytokines with age, sex and dental state of children and found a positive association of IL-1β, IL-6, IL-8, and IL-10 with gingivitis [25], which cohere with the finding d of the current study (although the current data failed to show statistically significant differences). The gene discussed is CXCL8; the disease is gingivitis.