The Jag1Ndr/Ndr immune system presents three T cell phenotypes which all could mitigate liver fibrosis: fewer and less activated CD8+ T cells which would otherwise promote liver fibrosis (Shivakumar et al, 2007) (Fig. 4F) and an increase in Tregs, which restrict liver fibrosis (Roh et al, 2014; Zhang and Zhang, 2020) (Fig. 4E,F). The gene discussed is CD8A; the disease is Hepatic fibrosis.