Liver damage in non-ALGS liver disease (using liver injury marker LGALS3BP) (B Yang et al, 2021), was positively correlated with recruitment of lymphocytes (including CD8A+, and FOXP3+ populations of T cells), as well as the extent of fibrosis (COL1A1 abundance) (Fig. EV5H). This evidence concerns the gene COL1A1 and liver disorder.