We observed a significant negative correlation (Pearson’s r ≤ −0.3 and P ≤ 0.01) between HLA-B gene expression and the degree of methylation in both the TSS1500 and the gene body region in the TCGA LUAD, LUSC and ER+ tumor samples (Supplementary Fig. 5–7). Here, HLA-B is linked to neoplasm.