We observed that LUAD and LUSC tumor regions with allelic HLA transcriptional repression had lower levels of infiltrating CD8 T cells compared to those without (LUAD, P = 1.3 × 10−6; LUSC, P = 0.015 and ER+, P = 0.25; Fig. 5d). The gene discussed is ESR1; the disease is neoplasm.