Notably, the levels of expression of these genes, added to six other genes involved in mitochondria activity (TST, NSUN3, GLMP and PTCD2), were reduced following the expression of HLA-G in the RCC7 cells (Table 2), consistent with mitochondrial impairment found in many types of cancer, particularly in ccRCC. Here, HLA-G is linked to nonpapillary renal cell carcinoma.