TMEM65 and Duchenne muscular dystrophy: While we did not confirm a reduced protein abundance corresponding to the decreased mRNA levels of Tmem65 in both BMD and DMD heart tissues, the delocalization of TMEM65 at the intercalated disks could explain the dystrophic cardiac phenotype that is reminiscent of the phenotype induced by knocking down Tmem65 (Teng et al, 2022).