GJA1 and familial dilated cardiomyopathy: Since the defect in complete localization of Cx43 has been associated with distinct forms of dilated heart caused by Lamin A/C or Dmd mutations (Gonzalez et al, 2018; Gonzalez et al, 2015; Le Dour et al, 2022), our findings underscore a shared mechanism contributing to DCM in those various genetic cardiomyopathies.