Since TMEM65 interacts and regulates Connexin-43 (Cx43) function in myocardium (Sharma et al, 2015), we found that Cx43 was more internalized in both BMD and DMD, with a lower co-localization with N-cadherin (NCAD), an intercalated disc marker (Fig. 6G–I). This evidence concerns the gene TMEM65 and Duchenne muscular dystrophy.