While EMI1 is traditionally described as an oncogene, given its overexpression induces CIN and tumourigenesis [31], there is a lack of information regarding its potential as a tumour suppressor gene as it is frequently lost in many cancers [32], and reduced expression is predicted to underlie aberrant increases in oncoproteins that may promote CIN and cancer development. Here, FBXO5 is linked to neoplasm.