We previously determined that reduced expression of core members of the SCF complex (SKP1 [S-Phase Kinase Associated Protein 1]; CUL1 [Cullin 1]; F-box protein) induces CIN and cellular transformation in colorectal and ovarian cancer contexts, supporting the possibility that they are aberrant aetiological events underlying early disease development [15–17]. The gene discussed is CUL1; the disease is cervical squamous intraepithelial neoplasia.