C/EBPs have been shown to increase upon myocardial ischemia, and inhibition of C/EBP signaling preserved cardiac function post-infarction.38 Similarly, ankyrin repeat domain 1 (Ankrd1) was among the genes in hearts of Cyp2c70−/− mice which most strongly correlated with plasma BAs (Fig. 5c). This evidence concerns the gene ANKRD1 and myocardial ischemia.