Our further analysis of these individuals using the UKB WES data indicated that this group is enriched for some known pathogenic variants causing disorders with higher prevalence in Ashkenazi Jewish (AJ) individuals, including a frameshift variant in the HEXA gene causing Tay-Sachs disease (rs387906309, ~50x enrichment in our Jewish ancestry group compared to Central London) and a missense variant in the GBA gene causing Gaucher disease, Type I (rs76763715, ~13x enrichment). Here, HEXA is linked to Tay-Sachs disease.