MAPK8 and head and neck squamous cell carcinoma: In both patients, ATAC-seq displayed that the differentiation of HNSCC cells made OCRs accessible that are associated with epithelial cell differentiation, cell adhesion, and stress-associated pathways, which included the regulation of response to wounding, programmed cell death, response to TGFβ, regulation of JNK cascade, and transmembrane receptor tyrosine kinase signaling (Fig. 2D, Supplementary Tables S4–S7).