TAAR1 and major depressive disorder: TAAR1 Dysfunction is implicated in psychiatricdisorders such asschizophrenia, depression, and addiction.36−38 TAAR1 activationhas been found to attenuate psychostimulant-associated abuse behavior,whereas knockout of TAAR1 potentiates it.18 In the last decades, several full and partial TAAR1 agonists havebeen synthesized.26,39−44 For example, the efficacy of full agonist RO5256390 is similar tothat of the endogenous TAAR1 agonist PEA, whereas the partial agonistRO5263397 shows lower efficacy.