TAAR1 and major depressive disorder: These selective TAAR1 agonists notonly improve schizophrenic behavior but also attenuate cocaine, METH,and nicotine addiction.17,45 Because TAAR1 playsin mood, behavior, and cognition, agonists that selectively targetTAAR1 show promise in treating psychiatric disorders such as schizophrenia,depression, and addiction.17−19,46−48 Therefore, understanding the molecular mechanismof binding of METH to TAAR1 is important.