CD274 and neoplasm: CPS is defined as the number of positive tumor cells, lymphocytes, and macrophages divided by the total number of viable tumor cells, multiplied by 100.26 CPS was employed in three studies,11,21,22 with positivity defined as ≥111,22 and ≥20.21 TPS corresponds to the number of positive tumor cells divided by the total number of viable tumor cells, multiplied by 100%.26 TPS was described in two studies, with positivity determined as ≥1%18 and the percentage of neoplastic cells expressing PD-L1 at any intensity.