Raschenberger et al. proposed that circumstances that lead to CKD development or are associated with CKD, such as activity of renin-angiotensin system, oxidative stress, or higher expression of p53, might have strong impact on TL.30 The results of this study are suggesting that BEN is associated with slower vascular aging where longer telomeres may partially explain this phenomenon. Here, REN is linked to chronic kidney disease.