NOS2 and neoplasm: In contrast, A1 and A2 neighborhoods derived from alive patient tumors (Supplementary Fig. S4H) had relatively high densities (up to >1,000 cells/mm2 in A1) of the CD8+NOS2−COX2− phenotype (Supplementary Fig. S4I), which corresponds with fully inflamed infiltrating CD8+ T cells that penetrated deep into the tumor core of low NOS2/COX2-expressing tumors (Supplementary Fig. S4J).