Fig. 3D shows the ratio of phenotype profiles in D3 neighborhoods relative to all alive neighborhoods (A1 + A2). This analysis reveals ∼10-fold increase in local densities of CD8−NOS2+COX2+ and CD8−NOS2+COX2− cells (metastatic niche), a >5-fold increase in CD8+NOS2+ cells (restricted inflamed tumor), and a >2-fold increase in CD8−NOS2−COX2+ cells (immune desert). D3 neighborhoods have less than 50% of the prosurvival phenotype CD8+NOS2−COX2− than A1 and A2 neighborhoods. The gene discussed is CD8A; the disease is neoplasm.