The PPI networks of the AKI and DKD groups were used to identify the following eight hub genes: ITGB6, actin beta (ACTB), Jun proto-oncogene, AP-1 transcription factor subunit (JUN), phosphoenolpyruvate carboxykinase 1 (PCK1), solute carrier family 34 member 1 (SLC34A1), secreted phosphoprotein 1 (SPP1), epidermal growth factor (EGF), and solute carrier family 12 member 3 (SLC12A3). The gene discussed is SPP1; the disease is diabetic kidney disease.