LRP1 locus was previously reported to be associated with migraine42 (odds ratio [OR], 1.11; P=1×10−90), FMD11 (OR, 1.33; P=2x10-10), SCAD43 (OR, 1.62; P=9×10−31), sporadic thoracic aortic dissection10 (OR, 1.21; P=3×10−8), and suggestively to cervical artery dissection44 (OR, 1.22; P=3×10−7), as summarized in Figure 1A. We applied conditional regression analyses using the GCTA-COJO software26 and confirmed a single genetic signal that involves rs11172113 as the lead variant in FMD and migraine signals, for which we had access to full summary statistics (Figure 1B; Figure S1). The gene discussed is LRP1; the disease is migraine disorder.