These data suggest a novel mechanism of retinal degeneration for prom1-null mutations and demonstrate that prom1-null frogs might also be a suitable model organism for the study of dry AMD-related hallmarks such as deposit formation, metabolic waste build-up within the RPE, RPE atrophy and non-neovascular retinal atrophy. This evidence concerns the gene PROM1 and dry age related macular degeneration.