This model also corresponds to the clinical manifestation of PROM1-associated retinal disease in humans, which is often diagnosed as cone-rod dystrophy, retinitis pigmentosa with cone involvement, or juvenile bull's eye macular degeneration (Permanyer et al., 2010; Pras et al., 2009; Zhang et al., 2007). This evidence concerns the gene PROM1 and Cone rod dystrophy.