In addition to a cone-rod dystrophy phenotype, SDD-like deposits were present in aging prom1-null frogs and were visible in histology (Figs 1–3), color fundus photography (Fig. 4A–C) and as hyper-reflective foci using infrared and spectral domain OCT (Fig. 4D–I). This evidence concerns the gene PROM1 and Cone rod dystrophy.