ANTXR2 and Hand-foot syndrome: Then, we identified 1,216 targets for HFS using Gene Cards, OMIM, TTD, Pharm GKB, and Drug Bank databases with the keyword “hand-foot syndrome.” The Venny 2.1.0 tool was used to intersect the 197 targets of SPSCG and 1,216 HFS-related targets, resulting in the identification of 40 overlapping targets (Figure 1A).