Beyond the mainstream hypotheses of Aβ cascade and abnormal tau protein phosphorylation (Ju and Tam, 2022), there are prominent theories regarding neuroinflammation (Self and Holtzman, 2023), mitochondrial dysfunction (Calvo-Rodriguez et al., 2024), and cholinergic hypotheses (Chen et al., 2023a), with the scientific community still actively investigating the pathogenesis of AD. Here, MAPT is linked to Alzheimer disease.