Diseases and symptoms with high GO term coverage are mostly inflammatory and painful diseases and symptoms, such as psoriatic arthritis, dysmenorrhea, cervical spondylosis, etc. Studies have shown that YXB has shown good anti-inflammatory and analgesic effects in animal experiments, and can increase the pain threshold and reduce foot swelling in mice with chronic inflammatory pain by inhibiting the expression of peripheral inflammatory factors such as TNF-α, IL-17A and CCL2 (Li R. et al., 2020; LI et al., 2021). This evidence concerns the gene TNF and psoriatic arthritis.