BRAF and neoplasm: In addition, for DTC <1 cm, the following factors should also be weighed in the decision for or against RAI (5): multifocality, capsule infiltration, infiltrative tumor growth, desmoplastic fibrosis, possibly BRAF V600E mutation, tumor diameter 6–10 mm, preoperative clinical carcinoma detection, a history of familiarity or percutaneous irradiation of the soft tissues of the neck.