In the univariate regression analyses, the highest OR of 10.846 (95% CI: 5.662–20.777, P < 0.001) for CKD was observed in the high VCAM-1 and low BDNF group, and it was followed by 5.840 (95% CI: 2.956–11.537, P < 0.001) in the high VCAM-1 and high BDNF group, and 2.712 (95% CI: 1.316–5.588, P = 0.007) in the low VCAM-1 and low BDNF group, compared with that in the low VCAM-1 and high BDNF group (Table 4). The gene discussed is BDNF; the disease is chronic kidney disease.