As a major aryl hydrocarbon receptor (AHR)-activating enzyme, IL4I1promotes tumor cell motility and suppresses adaptive immunity throughthe generation of indole metabolites and kynurenic acid [32].These amino acid metabolites, including indole-3-pyruvate (I3P) and 4-hydroxyphenylpyruvate (4HPP),have been shown to suppress ferroptosis induced by agents such as erastin orRas-selective lethal small molecule 3 (RSL3), significantly reducing lipidperoxidation [11]. The gene discussed is AHR; the disease is neoplasm.