SCN5A  (human sodium voltage-gated channel alpha subunit 5 gene) was found to be the major BrS-associated gene.This gene encodes the pore-forming α-subunit of the cardiacfast sodium channel and it is mutated in 20–30% of BrS patients [2, 22], whichcan eventually lead to sudden cardiac arrest due to ventricular arrhythmias[4, 5, 6]. This evidence concerns the gene SCN5A and sudden cardiac arrest.