MYH14 and rheumatic heart disease: While various substances, includingcardiac myosin, have been used as antigens to establish RHD models, a direct orside-by-side comparison assessing their safety, immune efficacy, effects on otherorgans, risks to researchers, and operational ease has not yet been conducted.Such comparative studies are crucial as they can identify the most effectiveantigens and contribute significantly to understanding the poorly understoodpathogenesis of RHD.