The iExosomes demonstrated specifically repressed KRAS activity in Panc-1 cells (with a KRASG12D mutation) by inhibiting cell proliferation and augmenting apoptosis, but not in normal pancreatic epithelial cells with wild-type KRAS (BxPC-3 cells (KRASWT)), MIA PaCa-2 (KRASG12C) Capan-1 (KRASG12V), cancer cells (Kamerkar et al., 2017). The gene discussed is KRAS; the disease is cancer.