TTR and primary hyperoxaluria type 1: A new epoch in siRNA-based therapeutics was launched with the FDA’s approval of the first siRNA-lipid nanoparticle complex drug, Patisiran, for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis (Hoy, 2018); and Givosiran, a siRNA-conjugated GalNAc ligand that enables asialoglycoprotein receptors-mediated targeted delivery to hepatocytes to treat acute hepatic porphyria (Honor et al., 2021); and lumasiran, a siRNA-conjugated GalNAc ligand for the treatment of primary hyperoxaluria type 1 (PH1) (Scott and Keam, 2021).