Lin et al. (2021) engineered iRGD-modified exosomes and encapsulated them with siRNA targeting CPT1A in colorectal cancer cells leading to CPT1A knockdown, suppressing FAO and reversing oxaliplatin resistance. iRGD-modified exosomes significantly suppressed the expression of CPT1A in tumor tissues, reversed oxaliplatin resistance, and inhibited tumor growth by inhibiting FAO with high safety in vivo. The gene discussed is CPT1A; the disease is neoplasm.