Additionally, the default mode network and its various nodes have been critically implicated in the early pathophysiological processes of AD, with both the accumulation of β-amyloid plaques and tau tangles disproportionally aggregating in the densely connected midline structures of the posteromedial cortices and the medial prefrontal cortex (Buckner et al., 2005; Elman et al., 2016), and the medial temporal (Adams et al., 2019; Kaufman et al., 2018), respectively. Here, MAPT is linked to Alzheimer disease.