Correlation analyses integrating gut bacterial community profiles, fecal metabolomics, and pharmacological indices from lung and intestinal tissues revealed significant associations between pro-inflammatory mediators IL-1β, TNF-α, and IL-6 in the pulmonary environment of ALI mice and fecal metabolites such as tryptophan, L-kynurenine, formyl-kynurenine, arachidonic acid, leukotriene C4, and 12-HpETE. The gene discussed is IL1B; the disease is acute respiratory distress syndrome.