OTULIN and staphylococcal infection: Whole-exome sequencing provided no molecular basis allowing for the diagnosis of IEI, and specifically no heterozygous defects in OTULIN, which are known to expose carriers to severe necrotic staphylococcal infections by dysregulating nonhematopoietic cells’ response to alpha-toxin, a major staphylococcal virulence factor (Spaan et al., 2022) (Supplementary Tables 1 and 2).