Prior findings reported that, in COVID-19, especially in severe patients, activation and exhaustion markers on the T cell surface were upregulated during acute infection, such as CD69, OX40, CD38, 4-1BB, PD-1, CTLA-4, LAG-3, TIM-3, and TIGIT (4, 14). The gene discussed is TNFRSF9; the disease is COVID-19.